H1 linker histones are highly abundant proteins that compact nucleosomes and chromatin to regulate DNA accessibility and transcription. However, the mechanisms that target H1 regulation to specific ...

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A new study finds that proteins known as linker histones control the complex coiling process that determines whether DNA will wind into long and thin chromosomes, made up of many small loops, or short ...

Linking is the process of combining various pieces of code and data together to form a single executable that can be loaded in memory. Linking can be done at compile time, at load time (by loaders) ...

Antibody-drug conjugate (ADC) developers say innovations to linkers, the proteins bridging antibodies to their therapeutic payloads, are opening the door to more stable, selective ADCs with ...

When developing antibody-drug conjugates (ADCs), the linker structure significantly influences stability, homogeneity, cytotoxic potency, tolerability, and pharmacokinetics (PK). Selecting the right ...